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KMID : 0359920140330040222
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Korean Journal of Nephrology
2014 Volume.33 No. 4 p.222 ~ p.225
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Toxic epidermal necrolysis associated with deflazacort therapy with nephrotic syndrome
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Lee Eun-Chae
Kim Geun-A
Koo Ja-Wook
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Abstract
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Toxic epidermal necrolysis (TEN) is a drug-related fatal disease. Extensive necrosis of the epidermis can lead to serious complications. This report describes two cases of TEN, associated with deflazacort (DFZ), in two boys, aged 4 years and 14 years, with nephrotic syndrome (NS). The 14-year-old male teenager received DFZ following NS relapse. After 17 days, pruritic papules appeared on the lower extremities. Another case involved a 4-year-old boy receiving DFZ and enalapril. After a 41-day DFZ treatment period, erythematous papules appeared on the palms and soles. Within 3 days, both boys developed widespread skin lesions (450%) and were admitted to the intensive care unit for resuscitative and supportive treatment. The patients showed improvement after intravenous immunoglobulin-G therapy. Owing to the rapid, fatal course of TEN, clinicians need to be aware of the adverse effects of this drug when treating cases of NS.
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KEYWORD
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Deflazacort, Intravenous immunoglobulin-G, Nephrotic syndrome, Toxic epidermal necrolysis
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